Once this seminal observation was established, it was only natural that the nonselective ОІ blocker propranolol and topical timolol in some cases be utilized, somewhat successfully, for a host of vascular disorders including pyogenic granuloma, Kaposiform hemangioendothelioma, tufted hemangioma, Kasabach Merritt syndrome, angiolymphoid hyperplasia with eosinophilia, Kaposi sarcoma, angiosarcoma, flushing, rosacea erythema, and adrenergic urticaria
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